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ea0073oc8.6 | Oral Communications 8: Pituitary and Neuroendocrinology | ECE2021

Increased PCSK1N in silent corticotroph pituitary adenomas may explain their “silence”

Ringvoll Normann Kjersti , Kristin Berland Astrid Berland , Olsen Linn Guro , Lekva Tove , Dahlberg Daniel , Bollerslev Jens , Petter Berg Jens , Cristina Olarescu Nicoleta

BackgroundCorticotroph pituitary adenomas present different degrees of functionality, from silent to whispering and finally to functioning adenomas leading to Cushing’s disease. Compared to their functioning (FCA) counterpart, the silent corticotroph adenomas (SCA) express lower levels of the corticotroph cell lineage marker–TBX19 (TPIT), proopiomelanocortin (POMC), and prohormone converting enzyme 1/3 (PC1/3, PCSK1)–t...
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Published by BioScientifica

Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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